Macrocycle Therapeutics to Treat Life-threatening Diseases

difficult-to-treat, life-threatening cytomegalovirus pneumonia in a patient with chronic renal disease

Failure to Treat Life-Threatening Ventricular Tachyarrhythmias in Contemporary Implantable Cardioverter–Defibrillators

BACKGROUND In clinical trials, manufacturer-specific, strategic programming of implantable cardioverter-defibrillators (ICDs), including faster detection rates, reduces unnecessary therapy but permits therapy for ventricular tachycardia/ventricular fibrillation (VF). Present consensus recommends a generic rate threshold between 185 and 200 beats per minute, which exceeds the rate tested in clin...

Diagnosing subtle forms of potentially life-threatening diseases.

ithin the first few months of my practice, I changed the ife of a young physician referred for right ventricular (RV) utflow tract ventricular tachycardia (VT) with the diagnois of arrhythmogenic right ventricular cardiomyopathy/ ysplasia (ARVC/D). This was an uncomfortable moment, ut not one nearly as bad as “the cardiologist’s worst ightmare” (1), making the opposite mistake of missing a ife-...

Enhanced cell therapy strategy to treat chronic limb-threatening ischemia.

Intermittent programmed compression of the chronically ischemic limb is associated with arteriogenesis. However, progenitor cell elements contributing to this neovascularization are typically diminished in number and function in the elderly dysvascular patient, particularly in the presence of diabetes, renal insufficiency, and cardiac disease. Granulocyte-colony stimulation factor (G-CSF) drama...

Life –threatening Necrotizing Fasciitis: a case report

Necrotizing fasciitis is characterized by a rapidly progressing necrosis of subcutaneous fat and fascia that rarely occurs in head and neck. It can be life threatening in the case of late diagnosis and antibiotic therapy and without surgical intervention. It is caused by group A streptococci or by a synergistic combination of aerobe and anaerobe microorganisms and bacterial synergy is an import...